Relationship between hypertension and inflammation
- VernacularTitle:高血压与炎症关系的研究进展
- Author:
Jinshou WU
;
Huashan HONG
- Publication Type:Journal Article
- Keywords:
hypertension;
inflammation;
cardiac fibrosis;
vascular remodeling
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory processes appear to play an important role in the pathogenesis of cardiovascular diseases.It has been established that inflammation has a pivotal role in the atherosclerosis.As a major risk factor contributed to atherosclerosis,hypertension seems to be a chronically low-grade inflammation process.Lots of studies suggested that blood pressure elevation is significantly positive correlation with the levels of inflammatory mediators,such as C-reactive protein.Inflammation may promote the process of hypertension.Furthermore,inflammation is highly associated with cardiac fibrosis and vascular remodeling in hypertension.Current clinical trials,for example,ASCOT-LLA suggested that use atorvastatin to reduce the inflammatory reaction in hypertensive patients with normal concentration of cholesterol would decrease the major cardiovascular events(relative risk reduction 36%).This paper summarizes the association inflammation with hypertension as well as cardiac fibrosis and vascular remodeling,and tries to explore the clinical significance of the association.
