Effect of losartan on mRNA expression of type 2 angiotensin II receptor and cytokines in diabetic rats kidney
- VernacularTitle:氯沙坦对糖尿病大鼠肾脏AT_2受体及细胞因子mRNA表达的影响
- Author:
Liansong NI
;
Jinchen ZHENG
;
Dawang WANG
;
Feixia SHEN
;
Anle LI
;
Jianbo WU
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
rats;
cytokines;
angiotensin Ⅱ;
receptor;
losartan
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of losartan on the mRNA expression of type 2 angiotensin II receptor and cytokines in diabetic rat kidney.METHODS: SD rats were randomly divided by following groups: control rats(group C),diabetic rats(group D) and diabetic rats treated with losartan (30(mg?kg~(-1)?d~(-1)),by gavage,group DT).At the end of 8-weeks study,mRNA expressions of the type 2 angiotensin II receptor(AT_2),transforming growth factor-?_1(TGF-?_1),platelet-derived growth factor-B(PDGF-B),tumor necrosis factor-?(TNF-?) and collagen Ⅳ in rats renal cortex were measured by RT-PCR,respectively.In addition,angiotensin Ⅱ level in renal cortex was determined by the radioimmunoassay.RESULTS: In group D,urine protein excretion(P
