Antioxidative effects of rosiglitazone on rat kidney with unilateral ureteral obstruction
- VernacularTitle:罗格列酮对单侧输尿管梗阻大鼠肾脏的抗氧化保护作用
- Author:
Qin LIN
- Publication Type:Journal Article
- Keywords:
rosiglitazone;
uriteral uretal obstruction;
oxidative stress;
malondialdehyde;
catalase;
superoxide dismutase
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the antioxidative effect of rosiglitazone(RSG),a new insulin sensitizer,on kidney of rats with unilateral ureteral obstruction(UUO).Methods: Male adult Sprague-Dawley rats were randomly divided into 3 groups: Sham-operated group(n=6),UUO model group(UUO model was established by ligating the left ureter,n=18),and UUO+RSG group(UUO model rats were treated with RSG,n=18).The latter 2 groups were divided into subgroups according to the times(3 d,7 d and 14 d) after intervention(n=6).Malondialdehyde(MDA),catalase(CAT) and superoxide dismutase(SOD) contents in the homogenized lysate of obstructive renal cortex were determined.Results: Compared with those in Sham-operated group,MDA contents in UUO group increased by 8.9(P=0.000),3.5(P=0.000) and 0.7 times on d 3,d 7 and d 14,respectively,while the contents of CAT and SOD decreased dramatically,with CAT contents reduced by 66.0%,(72.6%) and 83.8%,respectively(P=0.000) and SOD contents reduced by 42.0%,50.2% and 67.7%,respectively(P
