A unique inhibitor of fVⅡa/TF: Nematode Anticoagulant Protein c2
- VernacularTitle:一种独特的fⅦa/TF抑制剂:线虫抗凝血蛋白c2
- Author:
Huilan WANG
;
Lifei PENG
- Publication Type:Journal Article
- Keywords:
NAPc2;
structure and function;
functionary mechanism;
functionary property;
application
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Nematoda anticoagulant protein c2((NAPc2)) is a protein originally isolated from the canine hookworm Ancylostoma caninum.NAPc2 binds to a noncatalytic site on fⅩa then selectively inhibits fVⅡa/TF complex.NAPc2 is proven to be a safe and potent anticoagulant in Phase Ⅰ and Phase Ⅱ clinical trials,and it has prolonged elimination half-life(longer than 50 h).In a word,NAPc2 may play a promising role in the prevention and treatment of thrombosis,disseminated intravascular coagulopathies(DIC) and tumor.
