Study on the relationship between genetic polymorphisms of the ?_2-adrenoceptor and obesity in hypertensive patients
- VernacularTitle:高血压人群中?_2肾上腺素受体遗传多态性与肥胖相关性研究
- Author:
Wei MO
;
Jie LIU
;
Honghao ZHOU
;
Zhaoqian LIU
- Publication Type:Journal Article
- Keywords:
?_2-adrenoceptor;
genetic polymorphism;
haplotypes;
obesity;
hypertension
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim: Human ?_2-adrenoceptor contributes to the regulation of adipose tissue lipolysis,glucose homeostasis and vascular tension through endogenous catecholamines.This study was to investigate the association between polymorphisms of ?_2-adrenoceptor Arg16Gly and Gln27Glu and obesity in hypertensive patients.Methods Genotypes were determined using the PCR-RFLP and AS-PCR assay in 225 essential hypertensive patients and 125 healthy volunteers.Statistical analyses include one-way ANOVA and ?~2 analysis.Results The Arg16Gly and Gln27Glu polymorphisms were in Hardy-Weinberg equilibrium.The allele frequency of 27Glu in the patients with hypertension and obesity was 0.069 and significantly higher than that in the patients with hypertension and that in the healthy volunteers(P
