GABA_A receptor partially mediated propofol-induced hyperalgesia at ventrolateral periaqueductal gray(vlPAG) of rats
- VernacularTitle:GABA_A受体部分介导丙泊酚在中脑导水管周围灰质腹外侧区的致痛觉过敏作用
- Author:
Qinyun WANG
- Publication Type:Journal Article
- Keywords:
GABA_A receptor;
propofol;
bicuculline;
hyperalgesia;
hot plate test;
ventrolateral periaqueductal gray(vlPAG)
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of propofol on nociceptive response at ventrolateral periaqueductal gray(vlPAG) of rats and the possible role of GABA_A receptor in this prosses.Methods Sprague-Dawley(SD) female rats were randomized into each group.Bicuculline and propofol were microinjected into ventrolateral periaqueductal gray(vlPAG).The noxious response was evaluated by hot plate and formalin test.Fos-like immunoreactivity(FLI) neurons expressed in spinal dorsal horn(DH) induced by formalin intraplantar injection(sc) of one hindpaw were used as a neuroactive marker to observe the effects of propofol on the noxious transmission in DH.Results In hot-plate test,the hyperalgesia induced by propofol(10 g?L~(-1)) vlPAG microinjection was significantly antagonized about(70%),(71%) at 10 and 20 min after (bicu-)culline(25 mg?L~(-1)) vlPAG microinjection(P
