Effect of intracoronary carbachol administration on ventricular repolarisation in a sheep model
- VernacularTitle:冠脉内应用氨甲酰胆碱对心室复极的影响
- Author:
Lexin WANG
- Publication Type:Journal Article
- Keywords:
carbachol;
ventricular repolarisation;
activation-recovery interval;
nitric oxide;
cardiac electrophysiology
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of carbachol on ventricular repolarization in an intact animal heart.Methods In 4 sheep,carbachol was injected to the left circumflex coronary artery(LCX) at 1.0 mol?L~(-1) and 2.5 mol?L~(-1) respectively.Multiple unipolar ECGs were acquired from the epicardium of the LCX territory.Activation-recovery interval(ARI) was analysed from these ECGs.Administration with 2.5 mol?L~(-1) was also repeated after pre-treatment with nitro-L-arginine(20 mg?kg~(-1)),a nitric oxide synthase inhibitor.Results Intracoronary injection with carbachol at 1.0 mol?L~(-1) or 2.5 mol?L~(-1) increased ARI by(38?17) ms and(58?14) ms,respectively(P
