Changes of function and expression level of angiotensin Ⅱ type 1 receptor after sympathectomy in juvenile rats
- VernacularTitle:幼年大鼠交感神经损伤后血管紧张素受体功能及表达的变化
- Author:
Huiqing SHI
;
Fengci HE
- Publication Type:Journal Article
- Keywords:
angiotensin Ⅱ;
angiotensin Ⅱ type 1 receptor;
sympathectomy
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of sympathectomy on the function and the expression level of angiotensin Ⅱ type 1 receptor(AT_(1)R).Methods Newborn male Wistar rats' sympathetic nerve was destroyed by 6-hydroxydopamine(6-OHDA),and then following parameters were observed after 11 weeks: pressor and vasoconstrictive effects of AngⅡ,the affinity of -AngⅡ to AT_(1)R in myocardium,the level of mRNA expression of AT_(1)R in vessel smooth muscle.Results The pressor and vasoconstrictive effects induced by AngⅡand the mRNA expression of AT_(1)R in vessel smooth muscle enhanced substantially in adult rats who had been performed sympathectomy at juvenile period.There was also an enhancement in B_(max) of AT_(1)R in myocardium of the rats performed with sympathectomy,while no change occurred in K_(D).Conclusion In rats performed with sympathectomy,the expression level of AT_(1)R rises remarkably.The pressor and vasoconstrictive effects induced by AngⅡenhance consequently. These might be the reasons that blood pressure and heart rate do not reduce after sympathectomy.
