Construction of a new staging system for hepatocellular carcinoma
- VernacularTitle:一个新的肝癌分期系统的构建
- Author:
Baihong ZHANG
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
staging;
survival;
Cox regression analysis
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct a new staging scheme for patients with hepatocellular carcinoma(HCC).Methods A retrospective analysis of HCC cases from 1999 to 2003 was performed.The Cox model was used for multivariate analyses.The final model was derived from 10 randomly-chosen training samples and the prognostic validity of the new staging score was assessed on the corresponding testing samples.Results A simple scoring system was produced,assigning linear scores(0/1/2) to the covariates (TNM,?-fetoprotein,and Child-Pugh).Compared with Okuda stage and CLIP score,the new staging system,structured as a five-category tool,had a greater discriminant ability.Conclusion The new staging system,accounting for both liver function and tumor characteristics,can accurately identify patients with different prognoses,particularly in the advanced phases of HCC,thus representing a useful tool in the treatment of the disease.
