Association between the genetic polymorphisms of ?_2-adrenergic receptor and the chronic obstructive pulmonary disease.
- VernacularTitle:?_2-肾上腺素能受体基因多态性与慢性阻塞性肺疾病的关系
- Author:
Li MA
;
Duanxing FENG
;
Xiangyan ZHANG
- Publication Type:Journal Article
- Keywords:
Obstructive;
Lung disease;
?_2-adrenergic receptor;
Genetic polymorphism
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the genetic polymorphisms of ?_2-adrenergic receptor and the chronic obstructive pulmonary disease.Methods Allele specific-PCR technique was used to determine 16、27 locos of ?_2-AR genetic polymorphism in 64 unrelated patients with chronic obstructive pulmonary disease and 31 healthy controls in the Department of Respiratory Medicine,People's Hospital of Gui zhou province from Mar.2003 to Apr.2004.Results In COPD group and the healthy group the frequency of Gln/Gln genotype of ?_2-AR 27 locus was 42.86%and 19.35%respectively.It showed significantly difference between them(P
