Effect of ginkgo biloba extract on expression of Activin A in hepatic fibrosis of rat.
- VernacularTitle:银杏叶提取物对大鼠肝纤维化Activin A表达的影响
- Author:
Hao LIU
;
Zhaohong SHI
;
Jieping YU
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba extract;
Hepatic fibrosis;
Activin A
- From:
Chinese Journal of Practical Internal Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of EGB on hepatic fibrosis and expression of Activin A in rats with fibrosis.Methods From Oct.2004 to Apr.2005,the study was conducted in 30 adult male rats in the pepartment of Gastroenterology,the people's Hospital of Wuhan University.The rats were randomized into 3 groups:control group,model group and treatment group.Except the rats in the control group,others were induced to hepatic fibrosis by intraperitoneal injection of CCl_4 twice a week for 8 weeks.Those rats in the treatment group were intragastrically administered with EGB establish model of everyday.At the end of the 8th week,all rats were sacrificed.The samples of liver was staining with HE.The expression of Activin A was determined by immunohistochemistry and RT-PCR.Results The grade of fibrosis in EGB-treated groups were lower than that in the model group(P
