Astragulus & Angelica mixture enhances nitric oxide production and reduces angiotensin II in the kidney of UUO rats
- VernacularTitle:黄芪当归合剂对单侧输尿管梗阻大鼠肾脏血管活性物质变化的影响
- Author:
Liqiang MENG
;
Lei QU
;
Xiaomei LI
- Publication Type:Journal Article
- Keywords:
Astragalus;
Angelica;
Nitric oxide;
Angiotensin II;
Fibrosis
- From:
Chinese Journal of Nephrology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of Astragalus & Angelica (A&A) , the mixture of Chinese herbs, on different vasoconstrictors and vasodilators in the process of renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO). Methods Wistar rats were randomly divided into Sham,UUO and UAA (UUO+A&A) groups. After administration of A&A (14 g?kg-1?d-1) for 0, 3, 7 and 10 days, the levels of Ang-II , ET-1, nitric oxide(NO) and the activities of different NOS in renal homogenate were measured by RIA or enzyme method. The expression levels of eNOS, nNOS, iNOS were detected in the kidney by immunohistochemistry and semi-quantitively assessed by Western blot. Results After A&A administration, the levels of Ang- II and ET-1 were increased in UUO at all time points (P
