Expression of HLA-G mRNA and protein in ectopic and eutopic endometrium in patients with endometriosis
- VernacularTitle:HLA-G蛋白及基因在子宫内膜异位症在位和异位内膜中的表达
- Author:
Yanqiu WANG
;
Fuqi XING
;
Shiling CHEN
- Publication Type:Journal Article
- Keywords:
HLA-G antigens;
endometriosis;
in situ hybridization;
immunohistochemistry
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of human leucocyte antigen-G (HLA-G) in the endometrium of patients with endometriosis (EM). Methods The expression of HLA-G protein was detected in ovarian endometriosis (OEM) and adenomyosis (AM) using immunohistochemistry method, and the expression of HLA-G mRNA was detected using in situ hybridization technique (ISH), to compare with that in the endometrium of hysteromyoma as the control group. Results The rate of positive HLA-G expression in EM (including AM and OEM) was significantly higher than that in control group (P0.05). The expression of HLA-G protein showed no relation with different clinical phase or different endometrial cycle. Conclusion HLA-G is overexpressed in EM, which may play certain role in the pathogenesis of the disease.
