The ex vivo multiplication of ??T cell from the patient with nasopharyngeal carcinoma and its expression of V? gene
- VernacularTitle:鼻咽癌患者??T细胞体外扩增及V?亚型表达的研究
- Author:
Xiaolu WANG
;
Wei HE
;
Lianshan ZHANG
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
??T cell;
T cell expansion;
lymphocytes, tumor-infiltrating
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
80%). The resulting bulk cultures were mainly comprised of a CD56~- subset of ??T cells. The expression of V?1, V?2 and V?3 gene families in the ex vivo multiplied ??T cells from TIL and PBMC of patients with NPC, and PBMC of normal control was demonstrated by RT-PCR. Conclusion The ??TIL of NPC can be multiplied in vitro for the first time. The subsets (V?1, V?2 and V?3) of ??T cells from PBMC of healthy individuals, PBMC and TIL of patients with NPC, can also be multiplied in vitro, and the experiment lays an experimental foundation of using ??T cells for the cellular adoptive therapy in patients with NPC.
