Expression and significance of Fas,FasL,Bcl-2 and Bax in bladder cancer
- VernacularTitle:膀胱癌中Fas、FasL、Bcl-2及Bax的表达及意义
- Author:
Lei ZHANG
;
Gang LI
;
Lixin SHI
- Publication Type:Journal Article
- Keywords:
bladder neoplasms;
genes, fas;
genes, bcl-2;
genes, bax
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of Fas, FasL, Bcl-2 and Bax in transitional cell carcinoma of bladder and its clinical significance. Methods Immunohistochemistry method was used to detect the expression of Fas, FasL, Bcl-2 and Bax in 40 specimens of transitional cell carcinoma of bladder and 24 specimens of normal bladder mucosa tissue. Results The positive expression of Fas was detected both in transitional cell carcinonma of bladder and in normal bladder mucosa tissue, while FasL, Bcl-2 and Bax only in transitional cell carcinonma of bladder. The expression of Fas was significantly lower in careinoma of high-grade malignancy than in carcinoma of low-grade malignancy (P
