Clinical and pathological features of idiopathic membranous nephropathy which has not been able to diagnose only by light microscopy
- VernacularTitle:光镜未能诊断的膜性肾病临床病理分析(附9例报告)
- Author:
Diange LIU
;
Bicheng LIU
;
Li LI
- Publication Type:Journal Article
- Keywords:
Membranous nephropathy;
Light microscopy;
Immunofluorescence;
Electron microscopy
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical and pathological features of idiopathic membranous nephropathy(IMN),which has not been able to diagnose only by light microscopy.Methods Nine cases which has not been diagnosed as IMN only by light microscopy from January 1998 to March 2005 were selected.We analyzed their clinical manifestation and pathological findings.Results One case was 6-year old child,who had nephrotic syndrome(NS).The other 8 cases were 45~70 year old adult,their clinical diagnoses being chronic glomerulonephritis or asymptomatic hematuria and /or proteinuria.Light microscopic diagnoses were minor glomerular abnormalities and focal proliferative glomerulonephritis.Immunofluorescence demonstrated scattered granular deposits of IgG along the capillary walls.Under the electron microscopy,small high density deposits were observed along the basement membrane,mainly stage Ⅰand Ⅱ.2 cases were complicated with thin membrane disease.Conclusion Chronic glomerulonephritis or asymptomatic hematuria and /or proteinuria often mixes slightly with IMN which is difficult to be diagnosed clearly depending on simple light microscopy.Therefore,it is very important to diagnosis to perform immunofluorescence and electron microscopy further.
