Origin of hepatic stem cells in human hepatocellular carcinoma
- VernacularTitle:原发性肝癌不同病理组织类型中肝干细胞的起源分析
- Author:
Ge WANG
;
Jinyou SUO
;
Jing DENG
;
Jin YANG
;
Jijun ZHENG
;
Hongzhong WANG
;
Qing HU
;
Zengpeng LI
;
Hualiang XIAO
;
Don WANG
- Publication Type:Journal Article
- Keywords:
primary hepatic carcinoma;
hepatic stem cell;
carcinogenesis;
immunohistochemistry
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the activation, distribution, origin, and expression of hepatic stem cells(HSC)in different histological types of primary liver carcinomas. Methods The histological and immunohistochemical features of 94 cases of hepatocellular carcinoma (HCC), 12 cases of intrahepatic cholangiocarcinoma (ICC) and 10 cases of mixed hepatocarcinoma were examined by HE staining and immunohistochemistry SP method, with 5 cases of sclerotic liver and 4 cases of normal liver tissues as control. Results HSC expression was observed and the transfor mation from HSC to carcinoma cell was also noted in the liver. CK7, CK19, c-kit, Thy-1, and AFP were found expressed in different types of hepatic carcinomas and the greatest intensive expression was found in the mixed hepatocarcinoma (P
