Study on Inhabition Effect of Chitlsan Oligosaccharide on Tumour
- VernacularTitle:壳寡糖对肿瘤抑制作用实验研究
- Author:
Jie GUAN
;
Dianjun LI
;
Zhenkun FU
- Publication Type:Journal Article
- Keywords:
Chitlsan oligosaccharide;
Tumour;
Inhibition
- From:
Journal of Medical Research
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the inhibition effect of chitlsan oligosaccharide on tumour. Methods The growth of tumour were observed after chitlsan oligosaccharide was injected into abdominal cavity(ip) or introtumour of mice;And the anti proliferation activities of chitlsan oligosaccharide on cells were evaluated by means of MTT assay. Results Growth of tumour were inhibited by chitlsan oligosaccharide, necrosis was observed in the tumour tissue.Chitlsan oligosaccharide affected the growth of cell. The effect was related to concentration of chitlsan oligosaccharide,but not depending of culture time.The apoptosis of cells could be seen under the transmission electron.Conclusion Chitlsan oligosaccharide could inhibit the growth of tumour and might induce apoptosis of cell.
