A clinical study of lymphocytic ?-adrenoceptor and ?_1-adrenoceptor gene expression in patients with heart fuilure treated by different ?-adrenoceptor antagonists
- VernacularTitle:不同?-受体阻滞剂对心力衰竭患者?-受体与?_1-受体基因表达干预性研究
- Author:
Li SHI
;
Jun LI
;
Shu PENG
;
Jianxiong LIU
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
?-adrenoceptor antagonists;
?-adrenoceptor;
Gene expression
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study peripheral blood lymphocytic ?-adrenoceptor(?-AR) densities and ?_1-adrenoceptor gene(?_1-AR mRNA) expression levels in patients with heart failure,to investigate the influences of different ?-adrenoceptor antagonists in ?-AR densities and ?_1-AR mRNA expression levels.Methods 104 cases of patients with heart failure were randomly divided into non-?-adrenoceptor antagonist group(35 cases),metoprolol group(34 cases) and carvedilol group(35 cases),we repeatly determined the ?-AR densities and ?_1-AR mRNA expression levels after two-month therapy.Results The ?-AR densities and ?_1-AR mRNA expression levels in heart failure group reduced significantly compared to these in normal persons(P0.05).After two-month therapy,?-AR densities and ?_1-AR mRNA expression levels in metoprolol group were significantly higher than those in carvendilol group and non-?-adrenoceptor antagonist group(P0.05).Conclusions The peripheral blood lymphocytic ?-AR densities and ?_1-AR mRNA expression level down-regulates in heart failure,which correlate with the severity of heart failure but etiological factors.Metoprolol can up-regulate the ?-AR densities and ?_1-AR mRNA expression level,whereas carvedilol has no such effects.
