Effects of Polysaccharide from B.Jiangsiensis to the immune deficit mouse's specific immunological function
- VernacularTitle:天螺霜对免疫功能低下小鼠模型特异性免疫功能的影响
- Author:
Chao ZHANG
;
Qingzhi LING
;
Min LUO
;
Tianyi CHEN
- Publication Type:Journal Article
- Keywords:
Polysaccharide from B.jiangsiensis/pharmacology;
Hemolysin;
Delayed hypersensitivity reaction;
Disease models,animal;
Mouse
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the enhanced effect of polysaccharide from B.jiangsiensis(PBJ) on the immune hypofunction mouse models and its dose-effect relationship.Methods The immune hypofunction mouse models were made by hypodermic injection with cyclophosphamide(Cy) in mice.PBJ's effect on hemolysin content in mouse body induced by chicken erythrocytes and the delayed-type hypersensitivity(DTH) induced by dinitrochlorobenzene in mice were observed and contrasted in the different mouse groups treated with Cy in vivo by hypodermic injection together with PBJ at doses of 400mg/kg,200mg/kg and 50mg/kg,respectively.Results The test showed that the index of hemolysin,hemolytic plaque formation and delayed hypersensitivity reaction in model group markedly decreased while the indexes of hemolysin test in the control group,high and middle dose groups increased(P
