Clinical pathological analysis of singularity uterine leiomyoma
- VernacularTitle:奇异性子宫平滑肌瘤15例临床病理分析
- Author:
Li LIANG
;
Ming SU
- Publication Type:Journal Article
- Keywords:
Uterus;
Leiomyoma;
Pathology,clinical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical and pathological characteristics of singularity uterine leiomyoma.Methods The cause of disease and the clinical features in 15 patients with singularity uterine leiomyoma were analyzed.The patients were examined by pathology and immunohistochemistry.Results The main clinical manifestations were irregular vaginal bleeding,pelvic tumor and anemia.3 patients combined with pregnancy,4 patients had the treatment history of exogenous progesterone.The tumor appeared grayish red,and with complete envelope by macroscopic examination;The multi-and mono-nucleated giant cells were seen under surgical microscopy,the mitosis count was 0～3/10HPF.The tumors showed weak positive staining for Ki-67 and p53,negative staining for ER in 8 cases and positive staining for PR in all cases.Conclusions Singularity uterine leiomyoma belongs to benign tumor,its clinical features and treatments are similar to common leiomyoma;It has certain relation with exogenous and endogenous progesterone.The differentiation of leiomyoma with leiomyosarcoma is basically depended on HE staining observation;The immunohistochemistry of leiomyoma has certain feature.
