Meta-analysis of effectiveness of fluoxetine in treatment of post-stroke depression
- VernacularTitle:氟西汀治疗脑卒中后抑郁对照研究的Meta分析
- Author:
Yabin JIANG
- Publication Type:Journal Article
- Keywords:
stroke;
depression;
fluoxetine;
neurological function;
Metaanalysis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To further investigate the effectiveness and safety of fluoxetine in treatment of post-stroke depression(PSD).METHODS: The effectiveness and safety of fluoxetine in treatment of PSD patients in 13 controlled studies were analyzed by meta-analysis again in order to assess the comprehensively significant differences and effect size(ES).RESULTS:(1)The scores of Hamilton,and degrees of neurological functional defect and Barthel index in PSD patients before and after treatment with fluoxetine had significant difference(P(0.8).(2)Improving degrees of depression symptom,neurological functional defect and activity of daily living scale(ADL) between fluoxetine treatment group and control group had significant difference(P(0.8).CONCLUSION: Fluoxetine can significantly ameliorate the depression symptom,neurological functional defect and ADL of patients with PSD,and it has few side effects.
