Correlation of nuclear DNA contents and p53 protein expression with CT image and prognosis of patients with epithelial ovarian tumors
- VernacularTitle:卵巢上皮性肿瘤核DNA含量、p53蛋白表达与其CT表现、预后的关系
- Author:
Kuiming JIANG
- Publication Type:Journal Article
- Keywords:
ovarian neoplasms;
neoplasms,glandular and epithelial;
DNA,neoplasm;
p53 protein;
tomography;
prognosis
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the nuclear DNA contents and expression of p53 protein in epithelial ovarian tumors(EOT) and to explore their correlation with CT images and prognosis in EOT patients.Methods: The nuclear DNA contents,expression of p53 protein and CT findings of 88 EOT patients were analyzed.Twenty-six EOT patients were followed up and were divided into AT group(aneuploid,n=19) and DT group(diploid,n=7) according to DNA ploid,and into p53 protein(+) group(n=15) and p53 protein(-) group(n=11) according to expression of p53 protein.The correlation of nuclear DNA content and p53 protein expression with CT findings and prognosis of EOT patients was analyzed.Results: The DNA index,patient number with AT and protein p53(+) rate were significantly different between patients with their cystic wall thickness≥3 mm and
