Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress.
10.4062/biomolther.2014.130
- Author:
Susara Ruwan Kumara MADDUMA HEWAGE
1
;
Mei Jing PIAO
;
Ki Cheon KIM
;
Ji Won CHA
;
Xia HAN
;
Yung Hyun CHOI
;
Sungwook CHAE
;
Jin Won HYUN
Author Information
1. Jeju National University School of Medicine, Jeju 690-756, Republic of Korea. jinwonh@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Apoptosis;
Galangin;
Human keratinocytes;
Oxidative damage;
Ultraviolet B
- MeSH:
Antioxidants;
Apoptosis;
DNA;
Free Radicals;
Humans;
Keratinocytes*;
Oxidative Stress*;
Phytochemicals;
Reactive Oxygen Species;
Skin
- From:Biomolecules & Therapeutics
2015;23(2):165-173
- CountryRepublic of Korea
- Language:English
-
Abstract:
Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
