Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues.
10.4062/biomolther.2014.108
- Author:
Seong Hyun CHOI
1
;
Jeong Su MOON
;
Byung Suk JEON
;
Yeon Jeong JEON
;
Byung Il YOON
;
Chang Jin LIM
Author Information
1. Biopid Co., Shinbuk, Chuncheon 200-832, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Phospholipid;
Hair growth-promoting effect;
Hair follicle;
Dermal papilla cell
- MeSH:
Animals;
Hair Follicle;
Hair*;
Humans;
Lung*;
Mice;
Mice, Inbred C3H;
Minoxidil;
Phosphatidylcholines;
Phospholipids*;
Skin
- From:Biomolecules & Therapeutics
2015;23(2):174-179
- CountryRepublic of Korea
- Language:English
-
Abstract:
BP201, porcine lung tissue-derived phospholipids, consists of phosphatidylcholine as a major phospholipid species. BP201 promoted hair growth after application onto the shaved backs of BALB/c and C3H mice. Its effect was enhanced when applied together with minoxidil (MNX) in C3H mice. When the tissue specimens prepared from the shaved skins of BP201-treated and control mice were microscopically examined, the total numbers of hair follicles in both anagen and telogen phases of BP201-treated mice were significantly higher than those of control mice. The numbers of hair follicles in the anagen phase of BP201-treated mice were also higher than those of control mice. In combination with MNX, BP201 further increased the total number of hair follicles, but did not alter the percentage of hair follicles in the anagenic phase. BP201 also increased the proliferation of human hair follicle dermal papilla cells. Collectively, BP201 possesses hair growth promoting potential, which would suggest its use singly or in combination for hair growth products.
