Effects of anti-morphine vaccines on pharmacological actions of morphine in mice
- VernacularTitle:吗啡疫苗接种小鼠对吗啡药理作用的影响
- Author:
Lin LI
;
Jiangping XU
;
Ning FU
- Publication Type:Journal Article
- Keywords:
morphine;
vaccine;
immunotherapy;
withdrawal syndrome
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of anti-morphine vaccines on pharmacological actions of morphine in mice.Methods Morphine-6-succinyl and morphine were conjugated respectively with Blue Carrier(BC) in the presence of carbodi-imide.After being immunized with both vaccines(M-BC,M-6-S-BC),the withdrawal syndrome and the abirritation were observed in mice.Results The withdrawal syndrome of the immune mice with M-6-S-BC and M-BC vaccines were reduced markedly compared with the model group,the skipping times were decreased and the latency was longer(P
