Protective effects of pharmacological preconditioningof total flavone of abelmoschus Manihot L medic on myocardial reperfusion injury in rabbits
- VernacularTitle:黄蜀葵花总黄酮预处理对家兔心肌缺血再灌注损伤的影响
- Author:
Li FAN
;
Yan GUO
;
Zhiwu CHEN
;
Chuangeng MA
- Publication Type:Journal Article
- Keywords:
TFA;
pharmacological preconditioning(PP);
ischemical reperfusion injury(IRI);
lipid peroxidation;
ICAM-1
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the protective effect and possible mechanisms of Total Flavone of Abelmoschus Manihot L medic(TFA) on myocardial reperfusion injury in rabbits,when it was given as a preconditioning inducer.Method Different doses of TFA were perfused intravenously lasting for 5 min,followed by a 10 min break before 30 min ischemia and 60 min reperfusion in rabbits.Using this preconditioning method,we observed the histo-pathological changes of myocardium,the content of MDA,the activities of SOD and GSH-PX in plasma,and also,the expression of ICAM-1 in myocardium.Results TFA(16,8 and 4 mg?kg~(-1)) significantly ameliorated myocardium ischemical reperfusion injury.The activities of SOD and GSH-PX in plasma were enhanced,while the MDA level was decreased.Meanwhile,the expression of ICAM-1 mRNA in myocardium was down-regulated.Conclusion Pharmacological preconditioning of TFA could protects myocardial ischemic reperfusion injury in rabbits by inhibiting lipid peroxidation and myocardium inflammatory reaction.
