Cysteine and arginine in plasma albumin are the major targets attacked by free radicals
- VernacularTitle:血浆白蛋白中胱氨酸和精氨酸是主要的氧化剂攻击基团
- Author:
Yanwen LU
;
Qiuyu ZHU
;
Feng DING
;
Yong GU
;
Shanyan LIN
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Amino acids;
Protein hydrolysates;
Carbonyls;
Advanced oxidative protein products
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of oxidants on the structure of albumin. Methods Using both AOPPs and protein carbonyl content as indices. The oxidative stress level in normal controls and uremia patients was evaluated. Albumin in plasma was purified by HPLC and then was subjected to amino acids composition assay. Results Both AOPPs level and protein carbonyl content in uremic patients were significantly higher than those in controls (P
