Blood supply analysis based on quantitative dynamic contrast-enhanced MRI in hepatocellular carcinoma
- VernacularTitle:肝细胞癌动态增强MRI定量分析的血供基础实验研究
- Author:
Jing WEI
;
Liguang ZOU
;
Cuiwei LIAO
;
Li WEN
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
magnetic resonance imaging;
dynamic;
microvessel density
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the status of blood supply at appearance of the first enhanced signal on dynamic contrast-enhanced MRI of hepatic cell cancer(HCC) of differentiated degree.Methods HCC was induced chronically with 1 ml of 2% DEN solution once a day in 80 rats for 14 weeks,and another 10 rats served as normal controls.All rats received dynamic contrast-enhanced MRI examination on week 16,18,20,21,22,23,24,25.The time-intensity curve was drawn and the slope rate of the first enhanced signal(S_(first)) was counted,then specimens were taken and observed of microvessel density(MVD) with light microscope.Results The differentiated degree of HCC was correlated with S_(first) and MVD.The poorer HCC differentiation,the bigger S_(first).Well differentiated HCC had low MVD,while poorly differentiated had higher MVD.Conclusion MVD is the main influence factor for that the S_(first) were significantly different between HCC of differentiated degree.
