Antagonizing effects of GSH against rat lymphocytotoxicity induced by sulfur mustard
- VernacularTitle:还原型谷胱甘肽对抗硫芥诱导大鼠脾淋巴细胞毒性作用
- Author:
Hui ZENG
- Publication Type:Journal Article
- Keywords:
sulfur mustard;
lymphocyte;
GSH;
mitochondria function;
DNA ladder
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of GSH on the mitochondria in rat lymphocyte in vitro.Methods Rat spleen lymphocytes were isolated by density gradient centrifugation and cultured with sulfur mustard of 100,500,1000 ?mol/L in vitro.The mitochondria function was detected by MTT.The changes of GSH were detected by fluorescence spectrophotometry and DNA fragments were also detected.Results There was a positive line correlation between the changes of mitochondria function and the GSH content(P
