Effect of hypoxia preconditioning on the biological activity of rat bone marrow derived endothelial progenitor cells.
- VernacularTitle:低氧预刺激对大鼠骨髓源性内皮祖细胞生物学活性的影响
- Author:
Yi LI
;
Yaling HAN
;
Jian KANG
- Publication Type:Journal Article
- Keywords:
Hypoxia;
Endothelial progenitor cells;
Stem cells;
Angiogenesis
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this investigation is to explore the effects of hypoxia on the biological activity of endothelial progenitor cells(EPC)and to improve the efficacy of EPC transplantation.Methods Rat bone marrow derived EPC were isolated and cultured either under normoxic or hypoxic conditions.The proliferation,migration and angiogenic ability of EPC were observed.Results In hypoxic group,the number of attached cells per high power field(hpf)was significantly more than that in normoxic group (91.0?8.0)vs(42.5?5.3),P
