Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats.
10.4062/biomolther.2014.134
- Author:
Keumhan NOH
1
;
Mahesh Raj NEPAL
;
Ki Sun JEONG
;
Sun A KIM
;
Yeon Ji UM
;
Chae Shin SEO
;
Mi Jeong KANG
;
Pil Hoon PARK
;
Wonku KANG
;
Hye Gwang JEONG
;
Tae Cheon JEONG
Author Information
1. College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea. taecheon@ynu.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Baicalin;
Baicalein;
Caffeine;
Drug interaction;
Pharmacokinetics
- MeSH:
Administration, Oral;
Animals;
Caffeine*;
Cytochrome P-450 CYP1A1;
Cytochrome P-450 CYP2B1;
Cytochrome P-450 CYP3A;
Cytochrome P-450 Enzyme System;
Drug Interactions;
Far East;
Herb-Drug Interactions;
Inhibitory Concentration 50;
Microsomes, Liver;
Pharmacokinetics*;
Plasma;
Rats*;
Scutellaria baicalensis;
Theobromine
- From:Biomolecules & Therapeutics
2015;23(2):201-206
- CountryRepublic of Korea
- Language:English
-
Abstract:
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the effects of these compounds on drug metabolizing enzymes, such as cytochrome P450 (CYP), for evaluating herb-drug interaction. The effects of baicalin and baicalein on activities of ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), benzyloxyresorufin O-debenzylase (BROD), p-nitrophenol hydroxylase and erythromycin N-demethylase were assessed in rat liver microsomes in the present study. In addition, the pharmacokinetics of caffeine and its three metabolites (i.e., paraxanthine, theobromine and theophylline) in baicalin-treated rats were compared with untreated control. As results, EROD, MROD and BROD activities were inhibited by both baicalin and baicalein. However, there were no significant differences in the pharmacokinetic parameters of oral caffeine and its three metabolites between control and baicalin-treated rats. When the plasma concentration of baicalin was determined, the maximum concentration of baicalin was below the estimated IC50 values observed in vitro. In conclusion, baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo, following single oral administration in rats.
