Prospective randomized clinical trial of non-small cell lung cancer for intraoperative radiotherapy
- VernacularTitle:非小细胞肺癌术中放疗的前瞻性研究
- Author:
Guixia ZHOU
;
Diwen ZENG
;
Lianyuan WANG
;
Lin MA
- Publication Type:Journal Article
- Keywords:
Lung neoplasms/surgery;
Lung neoplasms/radiotherapy;
Radiotherapy ,intraoperative;
Prognosis
- From:
Chinese Journal of Radiation Oncology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the long-term effect of non-small cell lung cancer treated with either postoperative irradiation(group A) or intraoperative radiotherapy(IORT) followed by postoperative irradiation(group B).Methods 154 patients with non-small cell lung carcinoma were randomized into two groups(groups A and B) with 77 patients in each.There were 134 squamous,17 adenocarcinoma and 3 adeno-squamous carcinoma.Seventeen patients had stage Ⅰ,76 stage Ⅱ and 61 stage Ⅲ lesions.The dose of postoperative irradiation in both groups was D_T4060?Gy.In group B,the IORT dose was 15-25?Gy,delivered by 9-16 ?MeV electrons.Results The local control rate was 49% and 62% in groups A and B,respectively(P0.05).Sixteen patients died of radiotherapy-induced complication: 2 in group A and 14 in group B.Conclusions Intraoperative radiotherapy followed by postoperative irradiation can enhance the local control rate of non-small cell lung cancer but can not improve the long term survival. The high complication mortality rate of IORT(18%) in contrast to that(3%) of postoperative radiotherapy is worth noticing.
