Impact of radiotherapy on myasthenia gravis in patients with malignant thymomas
- VernacularTitle:放疗恶性胸腺瘤对合并的重症肌无力的影响
- Author:
Xiuyu HOU
;
Yonggang XU
;
Hong GAO
;
Ming LI
;
Gaofeng LI
;
Mingyuan LIU
- Publication Type:Journal Article
- Keywords:
Thymus neoplasms/surgery;
Thymus neoplasms/radiotherapy;
Myasthenia gravis/chemotherapy;
Evaluation studies
- From:
Chinese Journal of Radiation Oncology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the change of myasthenia gravis(MG) during radiotherapy for patients with malignant thymomas.Methods Forty-five with malignant thymomas patients with were analyzed.The median total dose was DT54.2?Gy in 1.8-2.0?Gy /fraction,5 days a week.Anti-cholinesterase,such as pyridostigmine was used to control the MG symptoms.Results Forty-five patients completed radiotherapy on schedule except one from whom the treatment was was with drawn because of respiratory muscle involvement.Among these 44 patients,myasthenic symptom was relieved in 4 to various degrees,4 progressed,34 no change and 2 developed cholinergic crisis.Myasthenic symptom was not changed in one patient for whom radiotherapy had been standed before operation nor during the course of postoperative radiotherapy.Conclusions A course of radiotherapy of DT54.2?Gy,on fractionation of DT1.8-2.0?Gy modal would not aggravate myasthenia.However,proper use of anti-cholinesterase,careful observation and timely drug-adjustment are necessary.
