Pathophysiology and Apoptosis in Ischemic Stroke
- VernacularTitle:缺血性卒中的病理生理学机制与细胞凋亡
- Author:
Xinsheng DING
;
Meijiang FENG
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
excitatory amino acid;
free radical;
calcium overload;
gene;
apoptosis;
penumbra
- From:
International Journal of Cerebrovascular Diseases
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a very complex disorder with many intracellular and extracellular factors such as excitatory amino acids, free radicals, calcium overload, apoptotic genes and inflammation involved in its pathophysiological mechanisms. It has been reported that neuronal death mainly derives from necrosis and/or apoptosis after cerebral ischemia. Those neurons in the ischemic core usually suffer from necrosis, however, apoptosis (also referred to as delayed neuronal death) occurs in the ischemic penumbra, which has been the major therapeutic target in the ischemic stroke.
