The Effect of Maitork on Plasma Levels of Fibrinogen, GMP-140, tPA After Focal Cerebral Ischemia- Reperfusion in Rats
- VernacularTitle:美托康对局灶性脑缺血再灌注大鼠血浆中纤维蛋白原、GMP-140、tPA的影响
- Author:
Wei WANG
;
Qi WANG
;
Xiaokun QI
;
Feng QIU
;
Tianyu NI
- Publication Type:Journal Article
- Keywords:
Maitork;
cerebral ischemia;
fibrinogen;
platelet granule membrane protein 140;
tissue plasminogen activator
- From:
International Journal of Cerebrovascular Diseases
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of Maitork (a sodium chloride injection containing Ginkgo bioba extract and ligustrazine phosphate) on plasma levels of fibrinogen (Fg), platelet granule membrane protein 140 (GMP-140), tissue plasminogen activator (tPA) after focal cerebral ischemia-reperfusion in rats. Methods: Eighty male SD rats were randomly allocated into groups 3-day (n=40) and 7-day (n=40) after operation. Then each group was divided into 4 subgroups: sham-operation, ischemia control, Ginaton and Maitork. The focal cerebral ischemia model was established in rats. The activities of GMP-140 and tPA were measured by chromogenic substrate assay, and the level of Fg was measured by gel plaque assay. Results: The level of Fg in the Ginaton group was significantly higher than that in the ischemia control group, and the 7-day group was also significantly higher than that in the Maitork group (P
