Feature of VEGFR-3, podoplanin and CD34 positive vessels in colorectal cancer and their correlation with metastasis
- VernacularTitle:大肠癌VEGFR-3、podoplanin和CD34阳性脉管的特点及其与转移的关系
- Author:
Jianghong MU
;
Debing XIANG
;
Hualiang XIAO
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
vascular endothelial growth factor receptor-3;
podoplanin;
antigens, CD34;
tumor markers, biological;
neoplasm metastasis
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the characteristics of VEGFR-3, podoplanin or CD34 positive vessels in colorectal cancer (CRC) and their correlation with metastasis. Methods The characteristics of VEGFR-3, podoplanin or CD34 positive vessels in 96 cases with CRC and normal mucosa were evaluated by single-labeling or double-labeling immunohistochemistry with anti-human VEGFR-3, podoplanin or CD34 antibody respectively, and their relationship with metastasis of the cancer was analyzed. Results The density of VEGFR-3, podoplanin or CD34 positive vessels at the peripheral region of CRC was significantly higher than that of other regions of CRC or that in normal mucosa (P
