Molecular mechanisms of cancer cell methionine dependence
- VernacularTitle:肿瘤甲硫氨酸依赖性分子机制的研究进展
- Author:
Qiang LI
;
Weixin CAO
- Publication Type:Journal Article
- Keywords:
Cancer cells;
Methionine dependence;
Molecular events
- From:
Parenteral & Enteral Nutrition
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Methionine dependence is one of characteristic metabolism deficiency in cancer cells.Recently a series of researches focusing on key enzymes of methionine metabolism demonstrated that several molecular events might relate with cancer cell methionine dependence(i.e.,methionine synthasesingle nucleotide polymorphism,methythioadenosine phophorylasegene deletion,down regulation of thymidylate synthase translation;up regulation of methylenetetrahydrofolate reductase expression).Cell apoptosis induced by intracellular signal transduction dysfunction might be another potential mechanism.
