Improving effect of dexamethasone on hypoxia and pulmonary edema in rabbits with seawater drowning induced pulmonary edema
- VernacularTitle:地塞米松对海水淹溺性肺水肿兔缺氧及肺水肿的改善
- Author:
Xinmin DING
- Publication Type:Journal Article
- Keywords:
dexamethasone;
seawater;
drowning;
pulmonary edema
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the improving effect of dexamethasone on hypoxia and pulmonary edema in rabbits with seawater drowning induced pulmonary edema.Methods: Twenty-four ventilated New Zealand rabbits were instilled by seawater(4 ml/kg body weight) into lower trachea and were then equally randomized into the control group(CG) and the dexamethasone treatment group(DG).Rabbits in DG group were injected with dexamethasone(1 mg/kg body weight) on 20 min after seawater instillation and rabbits in CG group with 2 ml normal saline.PaO_(2),PaCO_(2),static compliance(C_(T)) and dynamic compliance(C_(D)) were observed before and after(20 min and 180 min) seawater drowning experiment;extravascular lung water index(EVLWI) and Evan's blue leakage index(ELI) were also determined in 2 groups.Results: At 180 min after seawater instillation,the PaO_(2),C_(T) and C_(D) in DG group were significantly higher and PaCO_(2)was significantly lower than those in CG group(P
