Effects of vecuronium on neuromuscular junction miniature endplate potentials and endplate potentials in rat diaphragm
- VernacularTitle:维库溴铵对大鼠膈肌神经肌肉接头微终板电位和终板电位幅度和频率的影响
- Author:
Jun LI
- Publication Type:Journal Article
- Keywords:
vecuronium;
endplate potentials;
miniature endplate potentials;
phrenic nerve
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of vecuronium on the electrophysiology in neuromuscular junction of rat diaphragm in an isolated non-uniform stretched muscle preparation(INSMP).Methods: The INSMP was made in healthy adult rats which were sacrificed rapidly.The amplitude and frequency of miniature endplate potentials(MEPP) and endplate potentials(EPP) were recorded before and after the INSMP was treated with vecuronium at 4.0 ?g/ml(4?ED_(95)),2.0 ?g/ml(2?ED_(95)),1.0 ?g/ml(1?ED_(95)),and 0.5 ?g/ml(0.5?ED_(95)) separately.Results: Vocuronium at 0.5 ?g/ml had no obvious effect on the amplitude and frequency of MEPP and the amplitude of EPP,but vocuronium at 1 ?g/ml had significant inhibitive effects on the amplitude and frequency of MEPP and the amplitude of EPP 5 min after treatment(P
