Preoperative evaluation of temporal lobe epilepsy with positron emission tomography/computer tomography
- VernacularTitle:~(18)F-FDG PET/CT在颞叶癫癎术前评定中的价值
- Author:
Zhaocong ZHENG
- Publication Type:Journal Article
- Keywords:
epilepsy,temporal lobe;
positron-emission tomography;
tomography,X-ray computed;
diagnosis
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the role of positron emission tomography/computer tomography(PET/CT) in localizing the epiletogenic cortex of the temporal lobe epilepsy(TLE) before operation.Methods: Electroencephalogram(EEG) examinations and PET/CT(Discovery LS PET/CT Scanning) scans was performed in 53 patients with clinically confirmed temporal lobe epilepsy.Electrocorticography(ECoG) was performed in 38 of the 53 patients undergoing neurosurgical therapy and pathlogical examination was also performed.Congruence between ECoG,pathological examination and PET/CT images was analyzed.Results: All 53 patients obtained clearly anatomic and functional images.Fifty patients(50/53,94.3%) had abnormal ~(18)F-FDG PET/CT metabolism(hypometabolism in 48 cases and hypermetabolism in 2).Among the 50 patients,42(85.0%)were also found positive by multiple kinds of EEG examinations,but only 32 of 42(64.0%)showed definite location,and 30 of 32 cases(93.8%) were in full accordance with PET/CT results.Thirty-two of the 38 patients undergoing neurosurgical therapy had complete or partial congruence between their ECoG and PET/CT results.All the patients were confirmed to have hippocampal sclerosis and atrophy.According to ECoG localization results,the specificity of PET/CT was 84.2%(32/38) in localizing epilepsy foci.Conclusion: ~(18)F-FDG PET/CT can make anatomic and functional localization of TLE.It is an effective,sensitive and non-invasive method,but its results must be confirmed by EEG before operation.
