Influence of single nucleotide polymorphisms of TNF and interleukin-10 genes on response to interferon-? therapy in patients with chronic hepatitis B infection
- VernacularTitle:慢性乙型肝炎患者?干扰素治疗应答与肿瘤坏死因子及白介素10单核苷酸多态性的相关性
- Author:
He GUO
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
interferon-?;
tumor necrosis factors;
interleukin-10;
polymorphism,single nucleotide
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of single nucleotide polymorphisms(SNPs) of tumor necrosis factor(TNF) and interleukin-10(IL-10) genes on response to interferon-? therapy in patients with chronic hepatitis B(HBV) infection.Methods: A total of 43 patients with chronic HBV infection undergoing interferon-? therapy were followed up for 6 months,and were divided into responding group(n=26) and non-responding group(n=17).Genomic DNA was extracted from each individual and genotyped using TaqMan assay for 2 promoter SNPs in TNF-? gene(TNF-?-238 and-308),1 in TNF-?(LTA) gene(LTA+723),and 1 in IL-10 gene(IL-10-592).Results: There were no significant differences between responders and non-responders in the distribution of the genotypes or alleles of the SNPs TNF-?-238,TNF-?-308 and LTA+723.However,the A allele of IL-10-592 was more frequent in the responders than in the non-responders(P
