Growing insights into acid-sensing ion channels
- VernacularTitle:酸敏感离子通道的研究进展
- Author:
Zheng ZHANG
;
Bingxiang CAI
;
Yongyuan GUAN
- Publication Type:Journal Article
- Keywords:
acid-sensing ion channels;
ASICs;
nociception;
ischemia
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Acid-sensing ion channels( ASICs )are ubiquitously expressed both in periphery nervous system, where they are involved in nociception,mechanosensation,inflammation ,cardiac angina, and in central nervous system,where they are essential to a variety of physiologic and pathophysiologic processes,such as synaptic plasticity ,learning ,memory and ischemic brain injury. Here in the article, we present a collection of key points about ASICs, ranging from molecular identity and expression, regulatory mechanisms responsible for channel gating to their multiple functions. Finally, a future prospect for the investigation of ASICs is outlined.
