Advanced study on the association between human ?3-adrenoceptor genetic polymorphism and diseases
- VernacularTitle:人类?3肾上腺素受体基因多态性与疾病相关性研究进展
- Author:
Wei MO
;
Honghao ZHOU
;
Zhaoqian LIU
- Publication Type:Journal Article
- Keywords:
?3-adrenoceptor;
genetic polymorphism;
obesity;
insulin resistance;
type 2 diabetes mellitus
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
The human ?3-adrenoceptor plays an important role in the regulation of energy mobilization and utilization. A missense mutation in codon 64 of the gene for the ?3-adrenoceptor with a replacement of tryptophan to arginine (Trp64Arg) was found. This polymorphism influences receptor function when expressed in artificial cell lines or in isolated human fat cells. It is associated with an earlier onset of type 2 diabetes mellitus, features of insulin resistance and tendency to gain weight. Recent evidences suggest that Trp64Arg has additive and interactive effects with a number of other candidate gene variants. The functional significance of human ?3-adrenoceptor polymorphism and its association with metabolic diseases are reviewed in this paper.
