Antioxidant and protective effects of LWMH-SOD on neurocytes
- VernacularTitle:低分子肝素超氧化物歧化酶结合物抗氧化损伤及对神经细胞的保护作用
- Author:
Jing SUN
;
Qingzhu ZHANG
;
Fengshan WANG
;
Yanna CHENG
- Publication Type:Journal Article
- Keywords:
LMWH-SOD;
cerebral cortical neurons;
oxygen and glucose deprivation
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the protective effects of LMWH-SOD(Low molecular weight heparin- Superoxide dismutase Conjugate)on the injuries induced by oxygen and glucose deprivation in cultured neurons. Methods The cortical neurons of fetal rat were cultured in vitro. The antioxidant and protective effects of LMWH-SOD were observed by treating neurons with oxygen and glucose deprivation. Results LMWH-SOD reduced the number of cell death and the efflux of LDH and the content of NO,MDA and increased the membrane fluidity after the injuries of cells. Conclusion LMWH-SOD has protective effects on cerebral cortical neurons through its action of scavenging free radicals.
