Effects of luteolin on expression of TGF-?1 mRNA in rats with pulmonary fibrosis
- VernacularTitle:木犀草素对实验性肺纤维化大鼠组织中TGF-?1mRNA表达的影响
- Author:
Guoqing GONG
;
Zhiyu QIAN
;
Shu ZHOU
- Publication Type:Journal Article
- Keywords:
luteolin;
pulmonary fibrosis;
TGF-?1
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of luteolin on the expression of TGF-?1 mRNA in rats with pulmonary fibrosis, and elaborate the molecular mechanism of luteolin in pulmonary fibrosis therapy. Methods The model of pulmonary fibrosis was established through instilling bleomycin intratracheally. After luteolin treatment, the pulmonary index and the content of hydroxyproline (HYP) were observed. The levels of TGF-?1 mRNA in pulmonary tissues were determined with RT-PCR. Results The pulmonary index and the content of HYP decreased markedly in pulmonary fibrosis rats treated with luteolin. Furthermore, luteolin inhibited evidently the expression of TGF-?1 mRNA in lung tissues with pulmonary fibrosis. Conclusion The molecular mechanism of luteolin in pulmonary fibrosis therapy was associated with inhibition of the expression of TGF-?1 mRNA.
