Effect of extract of astragalus on inflammatory factor and apoptosis after focal cerebral ischemia/reperfusion injury in rats
- VernacularTitle:黄芪提取物对大鼠局灶性脑缺血再灌注损伤后炎症因子及细胞凋亡的作用
- Author:
Yanyan YIN
;
Weiping LI
;
Shaobin WANG
;
Ting HE
;
Liang MING
- Publication Type:Journal Article
- Keywords:
extract of astragalus;
ischemia/reperfusion;
inflammatory factor;
apoptosis
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the mechanisms of protective effects of extract of astragalus against focal cerebral ischemia/reperfusion injury in rats. Methods Focal cerebral ischemia was induced by intraluminal thread occlusion of middle cerebral artery. Immunohistochemistry was used to determine expression of TNF-?,IL-1? was measured by radioimmunity, and the apoptosis was observed by TUNEL. Results EA(20、40、80 mg?kg -1,ig)could decrease the expression of TNF-? and the level of IL-1? and reduce cell apoptosis. Conclusion EA has inhibitory action on the increase in the expression of TNF-?,the level of IL-1? and the apoptosis of neurons induced by focal cerebral ischemia/reperfusion.
