EFFECTS OF POMEGRANATE PEEL EXTRACTS ON ANTIOXIDANT CAPACITY AND LIPID METABOLISM IN HYPERLIPIDEMIC MICE
- VernacularTitle:石榴皮提取物对高脂血症小鼠抗氧化功能和脂质代谢的影响
- Author:
Yunfeng LI
;
Changjiang GUO
;
Jijun YANG
;
Jingyu WEI
;
Jing XU
;
Shuang CHENG
- Publication Type:Journal Article
- Keywords:
pomegranate peel;
antioxidant capacity;
lipid metabolism
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of pomegranate peel extract on antioxidant capacity and lipid metabolism in C57BL/6J mice fed high fat diet in comparison with pomegranate juice extract. Method: The hyperlipidemic model was developed by feeding C57BL/6J mice a high fat diet. The effects of pomegranate peel extract (supplemented in drinking water) on serum FRAP value, paraoxonase(PON), GSH-Px and SOD activities as well as serum and hepatic lipids contents were observed. The morphologic change of aortic walls was also examined. Results: The antioxidant capacity and lipid metabolism were improved by supplementation of pomegranate peel extract in hyperlipidemic mice. The pathologic changes manifested in aortic walls were also inhibited. The pomegranate juice extract presented similar effects. Conclusion: The pomegranate peel extract inhibited the early process of atherosclerosis. The possible mechanisms were related to the improved antioxidant capacity and lipid metabolism.
