Effects of low-dose recombinant human growth hormone on acute phase response in patients with abdominal sepsis
- VernacularTitle:小剂量重组人生长激素对腹腔脓毒症病人急性相反应的影响
- Author:
Chaogang FAN
;
Jianan REN
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Growth hormone;
Abdominal sepsis;
Acute phase response
- From:
Parenteral & Enteral Nutrition
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the effects of recombinant human growth hormone on the acute phase response in abdominal sepsis patients.Methods: Prospective unblinded trial was made with each patient serving as his/her own control.Eighteen abdominal sepsis patients were enrolled ranging in age from 24 to 60 yrs.All patients received 10 U/d of GH 48 hrs after performing drainage and for 7days.Results: Serum concentration of constitutive proteins,acute phase protein and cytokines were measured before and 1,3,5 and 7 days after GH administration.GH notablely increased serum constitutive protein levels(prealbumin,transferrin,fibronectin) and decreased serum acute phase protein level(CRP).Cytokine TNF-?,IL-1? and IL-6 had significant change after GH administration,but the changes were not relative to the change of acute phase response.Conclusion: Low-dose rhGH effectively modulated the acute phase response by attenuating production of the hepatic acute phase protein and increasing the synthesis of constitutive proteins.
