The study of the molecular structure and function of intestinal epithelial tight junction proteins
- VernacularTitle:肠上皮细胞紧密连接的结构及功能研究进展
- Author:
Zhongwei ZHANG
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Intestinal epithelial cell;
Intestinal barrier;
Tight junction
- From:
Parenteral & Enteral Nutrition
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Tight junctions are the primary structure of intestional epithelial cells,which maintains the integrity of the epithelial cell layers.Besides claudins,occludins and ZO-1,more than 40 different proteins have been discovered.The tight junctions(TJs) serve not only as the barrier to the passage of ions and molecules through the paracellula pathway and maintenance of epithelial cell polarity,but also to integrate such diverse processes as cell growth and differentiation,tumor suppression,gene transcription.This review is about the recent discovery of TJ proteins and their functions,which will lead to the complement about intestinal barrier function.
